History 2025
Folates and Medical Foods:
A Brief History
For three decades combinations of folate/B6/B12 have been used in medical foods for the dietary management of chronic metabolic conditions. Addressing folate-related metabolic conditions has been very successful.
Folate medical foods are intended to address the downstream consequences of disturbances of folate metabolism, particularly the downstream disturbances resulting from reduced active folate availability. Many of the conditions that cause vision loss have a vascular component particularly vulnerable to folate metabolic shortages. These imbalances increase inflammation through the accumulation of excess homocysteine, c-reactive protein (CRP), and vascular endothelial growth factor (VEGF), all of which may cause damage to small blood vessels of the eye and visual system. Eventually, this damage becomes a significant factor in vision loss.
Ocufolin is a medical food specially formulated for the dietary management of metabolic disturbances leading to retinal ischemia.
By increasing active folate, inflammation is reduced, blood flow is improved, and vision is stabilized.
As a medical food, Ocufolin does not treat or mitigate any diseases, but instead provides the essential nutritional requirements to restore healthy folate metabolism often compromised in patients with retinal ischemia. This can be beneficial for vascular conditions like diabetic retinopathy, macular degeneration, low tension glaucoma, and retinal vein occlusion.
The principal ingredients in Ocufolin are the active forms of the vitamins B2, B6, folate, and B12, which increase available L-Methylfolate in ocular tissues. The downstream impact of this is to increase ocular blood flow, decrease inflammation, and decrease ischemia in patients with compromised folate metabolism due to disturbances of folate metabolism. Homocysteine elevation is strong evidence for folate metabolic disturbances.
The Bascom Palmer Eye Institute of the University of Florida and other universities in Europe have studied Ocufolin its effect upon ocular blood flow and inflammation. Several recent clinical trials were conducted to evaluate the impact of lowering homocysteine and managing inflammation in diabetic retinopathy patients associated with folate metabolic disturbances. They found that dietary management with Ocufolin improves blood flow, reduces inflammation and vision loss by stabilizing folate metabolism in patients who are unable to fully metabolize folate.
Ocufolin uses the active forms of four key dietary to increase L-Methylfolate transport across the blood retinal barrier. This is important for patients with common folate metabolic disturbances who often have resultant oxidative stress. They also often have ocular vascular diseases because the retinal tissues have the highest metabolic rate and oxidant generation in the body. The key ingredients with addition of other supportive anti-oxidants together address ischemic oxidative stress.
Ocufolin provides an innovative, safe, and low cost solution to protect vision in patients with common folate metabolic conditions causing oxidative stress. Ocufolin is made in the USA in a GMP certified facility subject to careful quality control. You can be assured of excellent ingredients provided at the dosage as labeled.
A product, no matter how effective, that is too expensive is of little use. Selling directly to doctors and pharmacies lowers the cost of Ocufolin to our patients. Ocufolin delivers real value that you can trust.