History

A Brief History

Many years ago, combinations of folate/B6/B12 were launched as prescription medical foods products. These products were often promoted for use in DPN (Diabetic Peripheral Neuropathy) and were studied in numerous trials for DPN patient management. In those early years, Neurologists and Podiatrists were often the biggest fans of this combination ingredient approach and they observed the direct benefits for many type-2 diabetes patients. We utilized these insights for restoring microvascular blood flow and adapted our formulation specifically to address microvascular needs of the eye. As eye care specialists, we believe that you are in a unique position to literally observe the microvascular improvement of Diabetic Retinopathy patients. GHF has sponsored several new clinical studies to reveal the value of homocysteine management in eye care and the dietary management of retinopathy patients.

The Homocysteine Story

As seen in the figure above, Folic Acid must complete a 7-step process in order to become the active form of folate (l-methylfolate) and play the role needed to effectively convert Hcy in the cellular methylation cycle. Both l-methylfolate and active form of B12 (methylcobalamin) work directly as cofactors needed to convert Hcy into methionine. This Hcy methylation encourages the retinal blood vessels to repair themselves and is also used in the production of DNA and in protein synthesis.

NOTE: the presence of MTHFR enzyme (genetic limitation for many patients with folate-related polymorphisms including C677T and A1298C) is usually the rate limiting factor in the methylation cycle for Hcy.

Elevated homocysteine (Hcy) is a driver of microvascular disease and impaired retinal perfusion. Elevated Hcy increases the risk of DR, vascular endothelial injury and the expression of VEGF. The Bascom Palmer Eye Institute has conducted several recent clinical trials to identify the value of lowering and managing homocysteine for diabetic retinopathy patients with MTHFR.

Global Healthcare Focus, LLC believes that Ocufolin® provides an effective solution to this modern health concern. We provide a product of excellent quality and the right dose. One of the reasons most medications are so expensive is that the chain of wholesale distributors double or triple the price. Direct wholesale distribution substantially reduces the cost of OcufolinTM to doctors, pharmacies, and patients Ocufolin® delivers real value that you can trust.